Publications | Andreas D. Meid

Transporting trial results to synthetic real-world populations in order to estimate real-world effectiveness of newly marketed medicines

Fri, 25 Jul 2025 00:00:00 +0000

Towards a prescribing monitoring system for medication safety evaluation within electronic health records: a scoping review

Wed, 02 Jul 2025 00:00:00 +0000

Testing Higher Doses of Sildenafil to Repair Brain Injury Secondary to Birth Asphyxia: An Open-Label Dose-Finding Phase 1b Clinical Trial-Sildenafil Administration to Treat Neonatal Encephalopathy-Study 02

Mon, 23 Jun 2025 00:00:00 +0000

Effect of the frequently used antiepileptic drugs carbamazepine, gabapentin, and pregabalin on the pharmacokinetics of edoxaban and other oral factor xa inhibitors in healthy volunteers

Fri, 11 Apr 2025 00:00:00 +0000

Phenotypes of Patients with Direct Oral Anticoagulant (DOAC) Underdosing in Atrial Fibrillation: Results from the ARENA Registry

Thu, 12 Dec 2024 00:00:00 +0000

Real-World Application of a Quantitative Systems Pharmacology (QSP) Model to Predict Potassium Concentrations from Electronic Health Records: A Pilot Case towards Prescribing Monitoring of Spironolactone

Wed, 07 Aug 2024 00:00:00 +0000

Effect of Clarithromycin, a Strong CYP3A and P-glycoprotein Inhibitor, on the Pharmacokinetics of Edoxaban in Healthy Volunteers and the Evaluation of the Drug Interaction with Other Oral Factor Xa Inhibitors by a Microdose Cocktail Approach

Thu, 01 Aug 2024 00:00:00 +0000

Quality of medication documentation in patientś discharge summaries after implementing new legal requirements

Thu, 01 Aug 2024 00:00:00 +0000

Identifying Predictors of Heart Failure Readmission in Patients From a Statutory Health Insurance Database: Retrospective Machine Learning Study

Tue, 23 Jul 2024 00:00:00 +0000

Event Analysis for Automated Estimation of Absent and Persistent Medication Alerts: Novel Methodology

Tue, 04 Jun 2024 00:00:00 +0000

Coadministration of fluconazole to boost subtherapeutic sirolimus concentrations

Fri, 19 Apr 2024 00:00:00 +0000

Feasibility and Safety of Sildenafil to Repair Brain Injury Secondary to Birth Asphyxia (SANE-01): A Randomized, Double-blind, Placebo-controlled Phase Ib Clinical Trial

Fri, 01 Mar 2024 00:00:00 +0000

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Effect of Tacrolimus Formulation (Prolonged-Release vs Immediate-Release) on Its Susceptibility to Drug-Drug Interactions with St. John's Wort

Thu, 04 Jan 2024 00:00:00 +0000

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Influence of a Short Course of Ritonavir Used as Booster in Antiviral Therapies Against SARS-CoV-2 on the Exposure of Atorvastatin and Rosuvastatin

Tue, 19 Dec 2023 00:00:00 +0000

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Proceedings of the International Ambulatory Drug Safety Symposium: Munich, Germany, June 2023

Thu, 02 Nov 2023 00:00:00 +0000

CYP3A and CYP2C19 Activity Determined by Microdosed Probe Drugs Accurately Predict Voriconazole Clearance in Healthy Adults

Fri, 01 Sep 2023 00:00:00 +0000

Physiology-based pharmacokinetic modelling and experimental data suggest that rifabutin alters dolutegravir kinetics by both P-glycoprotein induction and concurrent inhibition

Wed, 19 Apr 2023 00:00:00 +0000

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Mortality and Hospitalizations Among Patients Enrolled in an Interprofessional Medication Management Program-Results of the Medicines Initiative Saxony- Thuringia (Arzneimittelinitiative Sachsen-Thüringen, ARMIN)

Fri, 14 Apr 2023 00:00:00 +0000

Supplementary notes: none

Effect of Clarithromycin, a Strong CYP3A and P-glycoprotein Inhibitor, on the Pharmacokinetics of Edoxaban in Healthy Volunteers and the Evaluation of the Drug Interaction with Other Oral Factor Xa Inhibitors by a Microdose Cocktail Approach

Sat, 04 Mar 2023 00:00:00 +0000

Anticholinergic burden measures, symptoms, and fall-associated risk in older adults with polypharmacy: Development and validation of a prognostic model

Mon, 23 Jan 2023 00:00:00 +0000

Analysing and improving pre-operative medication management in cardiac surgery

Tue, 18 Oct 2022 00:00:00 +0000

Supplementary notes: none

Quantification of the Time Course of CYP3A Inhibition, Activation, and Induction Using a Population Pharmacokinetic Model of Microdosed Midazolam Continuous Infusion

Tue, 04 Oct 2022 00:00:00 +0000

Supplementary notes: none

A prediction model for nonpersistence or nonadherence to direct oral anticoagulants in hospitalized patients with atrial fibrillation

Sat, 01 Oct 2022 00:00:00 +0000

Supplementary notes: none

HIOPP-6 - a pilot study on the evaluation of an electronic tool to assess and reduce the complexity of drug treatment considering patients' views

Tue, 28 Jun 2022 00:00:00 +0000

Prevalence and patient-rated relevance of complexity factors in medication regimens of community-dwelling patients with polypharmacy

Wed, 27 Apr 2022 00:00:00 +0000

Predicting Hospital Readmissions from Health Insurance Claims Data: A Modeling Study Targeting Potentially Inappropriate Prescribing

Thu, 10 Feb 2022 00:00:00 +0000

Supplementary notes: none

Low exposure to direct oral anticoagulants is associated with ischemic stroke and its severity

Fri, 04 Feb 2022 00:00:00 +0000

Machine learning for tumor growth inhibition: Interpretable predictive models for transparency and reproducibility

Tue, 01 Feb 2022 00:00:00 +0000

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Can Machine Learning from Real-World Data Support Drug Treatment Decisions? A Prediction Modeling Case for Direct Oral Anticoagulants

Wed, 15 Dec 2021 00:00:00 +0000

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Teaching reproducible research for medical students and postgraduate pharmaceutical scientists

Thu, 09 Dec 2021 00:00:00 +0000

Differential effects of beta-blocker exposures in predicting specific readmissions for heart failure and myocardial infarction

Fri, 12 Nov 2021 00:00:00 +0000

Supplementary notes: none

The impact of a computerized physician order entry system implementation on 20 different criteria of medication documentation - a before-and-after study

Mon, 11 Oct 2021 00:00:00 +0000

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Renal Safety of Hydroxyethyl starch 130-0.42 After Cardiac Surgery: A Retrospective Cohort Analysis

Sun, 26 Sep 2021 00:00:00 +0000

Estimated Thresholds of Minimum Necessary Adherence for Effective Treatment with Direct Oral Anticoagulants - A Retrospective Cohort Study in Health Insurance Claims Data

Fri, 24 Sep 2021 00:00:00 +0000

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Predicting hospital admissions from individual patient data (IPD): an applied example to explore key elements driving external validity

Thu, 05 Aug 2021 00:00:00 +0000

Disease-dependent variations in the timing and causes of readmissions in Germany: A claims data analysis for six different conditions

Mon, 26 Apr 2021 00:00:00 +0000

Comparison of Five Lists to Identify Potentially Inappropriate Use of Non-Steroidal Anti-Inflammatory Drugs in Older Adults

Mon, 22 Mar 2021 00:00:00 +0000

A prognostic model predicted deterioration in health-related quality of life in older patients with multimorbidity and polypharmacy

Mon, 01 Feb 2021 00:00:00 +0000

Predicting negative health outcomes in older general practice patients with chronic illness: Rationale and development of the PROPERmed harmonized individual participant data database.

Fri, 15 Jan 2021 00:00:00 +0000

Are anticholinergic symptoms a risk factor for falls in older general practice patients with polypharmacy? Study protocol for the development and validation of a prognostic model

Thu, 14 Jan 2021 00:00:00 +0000

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Teaching reproducible research for medical students and postgraduate pharmaceutical scientists

Mon, 07 Dec 2020 00:00:00 +0000

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Using the Causal Inference Framework to Support Individualized Drug Treatment Decisions Based on Observational Healthcare Data

Mon, 02 Nov 2020 00:00:00 +0000

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How complete is the Germany-wide standardised medication list (Bundeseinheitlicher Medikationsplan)? An analysis at hospital admission

Tue, 06 Oct 2020 00:00:00 +0000

Composite midazolam and 1'-OH midazolam population pharmacokinetic model for constitutive, inhibited and induced CYP3A activity

Sat, 08 Aug 2020 00:00:00 +0000

Pain severity and analgesics use in the community-dwelling older population: a drug utilization study from Germany

Fri, 10 Jul 2020 00:00:00 +0000

New Insights Into the Pharmacokinetics of Vancomycin After Oral and Intravenous Administration: An Investigation in Beagle Dogs

Mon, 01 Jun 2020 00:00:00 +0000

A framework to build similarity-based cohorts for personalized treatment advice - a standardized, but flexible workflow with the R package SimBaCo

Fri, 29 May 2020 00:00:00 +0000

Osteoporotic hip fracture prediction from risk factors available in administrative claims data - A machine learning approach

Tue, 19 May 2020 00:00:00 +0000

Reporter cell assay-based functional quantification of TNF-α-antagonists in serum - a proof-of-principle study for adalimumab

Fri, 01 May 2020 00:00:00 +0000

Phase I/II intra-patient dose escalation study of vorinostat in children with relapsed solid tumor, lymphoma, or leukemia

Thu, 10 Oct 2019 00:00:00 +0000

Supplementary notes: -

Evidence for underuse and overuse of antidepressants in older adults: Results of a large population-based study

Mon, 01 Apr 2019 00:00:00 +0000

The Role of Adherence Thresholds for Development and Performance Aspects of a Prediction Model for Direct Oral Anticoagulation Adherence

Tue, 19 Feb 2019 00:00:00 +0000

Pill-count and the arithmetic of risk: Evidence that polypharmacy is a health status marker rather than a predictive surrogate for the risk of adverse drug events

Sat, 01 Dec 2018 00:00:00 +0000

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Prediction of Drug-Related Risks Using Clinical Context Information in Longitudinal Claims Data

Sat, 01 Dec 2018 00:00:00 +0000

Supplementary notes: none

Rivaroxaban and macitentan can be coadministered without dose adjustment but the combination of rivaroxaban and St John's wort should be avoided

Sat, 01 Dec 2018 00:00:00 +0000

Dried-Blood-Spot Technique to Monitor Direct Oral Anticoagulants: Clinical Validation of a UPLC-MS/MS-Based Assay

Tue, 07 Aug 2018 00:00:00 +0000

The impact of potentially inappropriate medication on the development of health care costs and its moderation by the number of prescribed substances. Results of a retrospective matched cohort study

Tue, 31 Jul 2018 00:00:00 +0000

Changes in prescribed medicines in older patients with multimorbidity and polypharmacy in general practice

Sat, 28 Jul 2018 00:00:00 +0000

Reality check of pharmacoepidemiological study results: prediction of medication risks for personalized treatment decisions in the age of big data

Thu, 01 Feb 2018 00:00:00 +0000

Combinations of QTc-prolonging drugs: towards disentangling pharmacokinetic and pharmacodynamic effects in their potentially additive nature

Fri, 01 Dec 2017 00:00:00 +0000

Association of preventable adverse drug events with inpatients' length of stay-A propensity-matched cohort study

Sun, 01 Oct 2017 00:00:00 +0000

Management of chronic pain using extended release tilidine : Quality of life and implication of comedication on tilidine metabolism

Sun, 01 Oct 2017 00:00:00 +0000

Real-world complexity of atrial fibrillation treatment with oral anticoagulants: design and interpretation of pharmacoepidemiological studies

Sun, 01 Oct 2017 00:00:00 +0000

Refining estimates of prescription durations by using observed covariates in pharmacoepidemiologic databases: Necessary refinements to stimulate alternative approaches

Fri, 01 Sep 2017 00:00:00 +0000

Intracellular vorinostat accumulation and its relationship to histone deacetylase activity in soft tissue sarcoma patients

Tue, 01 Aug 2017 00:00:00 +0000

Comparison of Nine Instruments to Calculate Anticholinergic Load in a Large Cohort of Older Outpatients: Association with Cognitive and Functional Decline, Falls, and Use of Laxatives

Mon, 01 May 2017 00:00:00 +0000

Health Service Use, Costs, and Adverse Events Associated with Potentially Inappropriate Medication in Old Age in Germany: Retrospective Matched Cohort Study

Sat, 01 Apr 2017 00:00:00 +0000

How can we define and analyse drug exposure more precisely to improve the prediction of hospitalizations in longitudinal (claims) data?

Wed, 01 Mar 2017 00:00:00 +0000

Investigating the Additive Interaction of QT-Prolonging Drugs in Older People Using Claims Data

Wed, 01 Feb 2017 00:00:00 +0000

Is Polypharmacy Associated with Frailty in Older People? Results From the ESTHER Cohort Study

Wed, 01 Feb 2017 00:00:00 +0000

Comparative evaluation of methods approximating drug prescription durations in claims data: modeling, simulation, and application to real data

Thu, 01 Dec 2016 00:00:00 +0000

SLCO1B1 Gene Variations Among Tanzanians, Ethiopians, and Europeans: Relevance for African and Worldwide Precision Medicine

Thu, 01 Sep 2016 00:00:00 +0000

Longitudinal evaluation of medication underuse in older outpatients and its association with quality of life

Fri, 01 Jul 2016 00:00:00 +0000

Age-Dependent Impact of Medication Underuse and Strategies for Improvement

Mon, 01 Feb 2016 00:00:00 +0000

Dried Blood Spot Technique for the Monitoring of Ambrisentan, Bosentan, Sildenafil, and Tadalafil in Patients with Pulmonary Arterial Hypertension

Tue, 15 Dec 2015 00:00:00 +0000

Role of NR1I2 (pregnane X receptor) polymorphisms in head and neck squamous cell carcinoma

Sun, 01 Nov 2015 00:00:00 +0000

The impact of pharmaceutical care interventions for medication underuse in older people: a systematic review and meta-analysis

Thu, 01 Oct 2015 00:00:00 +0000

Medication Underuse in Aging Outpatients with Cardiovascular Disease: Prevalence, Determinants, and Outcomes in a Prospective Cohort Study

Wed, 19 Aug 2015 00:00:00 +0000

Impact of an electronic clinical decision support system on workflow in antenatal care: the QUALMAT eCDSS in rural health care facilities in Ghana and Tanzania

Tue, 27 Jan 2015 00:00:00 +0000