Publications

(2025). Towards a prescribing monitoring system for medication safety evaluation within electronic health records: a scoping review. BMC Med Inform Decis Mak 2025;25:244.

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(2025). Testing Higher Doses of Sildenafil to Repair Brain Injury Secondary to Birth Asphyxia: An Open-Label Dose-Finding Phase 1b Clinical Trial-Sildenafil Administration to Treat Neonatal Encephalopathy-Study 02. J Pediatr 2025;285:114701.

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(2025). Effect of the frequently used antiepileptic drugs carbamazepine, gabapentin, and pregabalin on the pharmacokinetics of edoxaban and other oral factor xa inhibitors in healthy volunteers. Front Pharmacol 2025;16:1542063.

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(2024). Phenotypes of Patients with Direct Oral Anticoagulant (DOAC) Underdosing in Atrial Fibrillation: Results from the ARENA Registry. Clin Drug Investig 2025;45:29-43.

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(2024). Quality of medication documentation in patientś discharge summaries after implementing new legal requirements. Z Evid Fortbild Qual Gesundhwes 2024;188:1-13.

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(2024). Effect of Clarithromycin, a Strong CYP3A and P-glycoprotein Inhibitor, on the Pharmacokinetics of Edoxaban in Healthy Volunteers and the Evaluation of the Drug Interaction with Other Oral Factor Xa Inhibitors by a Microdose Cocktail Approach. Cardiovasc Drugs Ther 2024;38:747-756.

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(2024). Event Analysis for Automated Estimation of Absent and Persistent Medication Alerts: Novel Methodology. JMIR Med Inform 2024;12:e54428.

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(2024). Coadministration of fluconazole to boost subtherapeutic sirolimus concentrations. Pharmacol Res Perspect 2024;12:e1198.

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(2024). Feasibility and Safety of Sildenafil to Repair Brain Injury Secondary to Birth Asphyxia (SANE-01): A Randomized, Double-blind, Placebo-controlled Phase Ib Clinical Trial. J Pediatr 2024;266:113879.

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(2024). Effect of Tacrolimus Formulation (Prolonged-Release vs Immediate-Release) on Its Susceptibility to Drug-Drug Interactions with St. John's Wort. Clin Pharmacol Drug Dev 2024;13:297-306.

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(2023). Influence of a Short Course of Ritonavir Used as Booster in Antiviral Therapies Against SARS-CoV-2 on the Exposure of Atorvastatin and Rosuvastatin. Cardiovasc Drugs Ther 2023.

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(2023). Proceedings of the International Ambulatory Drug Safety Symposium: Munich, Germany, June 2023. Drug Saf 2023.

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(2023). CYP3A and CYP2C19 Activity Determined by Microdosed Probe Drugs Accurately Predict Voriconazole Clearance in Healthy Adults. Clin Pharmacokinet 2023;62:1305-1314.

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(2023). Anticholinergic burden measures, symptoms, and fall-associated risk in older adults with polypharmacy: Development and validation of a prognostic model. PLoS One 2023;18:e0280907.

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(2022). Analysing and improving pre-operative medication management in cardiac surgery. Br J Clin Pharmacol 2022.

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(2022). Quantification of the Time Course of CYP3A Inhibition, Activation, and Induction Using a Population Pharmacokinetic Model of Microdosed Midazolam Continuous Infusion. Clin Pharmacokinet 2022.

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(2022). HIOPP-6 - a pilot study on the evaluation of an electronic tool to assess and reduce the complexity of drug treatment considering patients' views. BMC Prim Care 23(1):164.

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(2022). Prevalence and patient-rated relevance of complexity factors in medication regimens of community-dwelling patients with polypharmacy. Eur J Clin Pharmacol 2022.

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(2022). Predicting Hospital Readmissions from Health Insurance Claims Data: A Modeling Study Targeting Potentially Inappropriate Prescribing. Methods Inf Med 2022.

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(2022). Low exposure to direct oral anticoagulants is associated with ischemic stroke and its severity. J Stroke 2022;24:88-97.

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(2021). Can Machine Learning from Real-World Data Support Drug Treatment Decisions? A Prediction Modeling Case for Direct Oral Anticoagulants. Med Decis Making 2022;42:587-598.

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(2021). The impact of a computerized physician order entry system implementation on 20 different criteria of medication documentation - a before-and-after study. BMC Med Inform Decis Mak 2021;21:279.

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(2021). Renal Safety of Hydroxyethyl starch 130-0.42 After Cardiac Surgery: A Retrospective Cohort Analysis. Drug Saf 2021.

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(2021). Predicting hospital admissions from individual patient data (IPD): an applied example to explore key elements driving external validity. BMJOpen 2021;e045572.

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(2021). Disease-dependent variations in the timing and causes of readmissions in Germany: A claims data analysis for six different conditions. PLoS One 2021;16:e0250298.

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(2021). Comparison of Five Lists to Identify Potentially Inappropriate Use of Non-Steroidal Anti-Inflammatory Drugs in Older Adults. Pain Med 2021.

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(2021). A prognostic model predicted deterioration in health-related quality of life in older patients with multimorbidity and polypharmacy. J Clin Epidemiol 2021;131:1-12.

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(2021). Predicting negative health outcomes in older general practice patients with chronic illness: Rationale and development of the PROPERmed harmonized individual participant data database.. Mech Ageing Dev. 2021 Mar;194:111436.

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(2021). Are anticholinergic symptoms a risk factor for falls in older general practice patients with polypharmacy? Study protocol for the development and validation of a prognostic model. Front Pharmacol 2020;11:577747.

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(2020). Using the Causal Inference Framework to Support Individualized Drug Treatment Decisions Based on Observational Healthcare Data. Clin Epidemiol 2020;12:1223-1234.

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(2020). How complete is the Germany-wide standardised medication list (Bundeseinheitlicher Medikationsplan)? An analysis at hospital admission. Dtsch Med Wochenschr 2020;145:e116-e122.

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(2020). Pain severity and analgesics use in the community-dwelling older population: a drug utilization study from Germany. Eur J Clin Pharmacol 2020;76:1695-1707.

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(2020). New Insights Into the Pharmacokinetics of Vancomycin After Oral and Intravenous Administration: An Investigation in Beagle Dogs. J Pharm Sci 109(6):2090-2094.

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(2020). Osteoporotic hip fracture prediction from risk factors available in administrative claims data - A machine learning approach. PLoS One 15(5):e0232969.

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(2020). Reporter cell assay-based functional quantification of TNF-α-antagonists in serum - a proof-of-principle study for adalimumab. Anal Biochem 596:113646.

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(2019). Phase I/II intra-patient dose escalation study of vorinostat in children with relapsed solid tumor, lymphoma, or leukemia. Clin Epigenetics 11(1):188.

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(2019). Evidence for underuse and overuse of antidepressants in older adults: Results of a large population-based study. Int J Geriatr Psychiatry 34(4):539-547.

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(2018). Rivaroxaban and macitentan can be coadministered without dose adjustment but the combination of rivaroxaban and St John's wort should be avoided. Br J Clin Pharmacol 84(12):2903-2913.

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(2018). Prediction of Drug-Related Risks Using Clinical Context Information in Longitudinal Claims Data. Value Health 21(12):1390-1398.

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(2018). Dried-Blood-Spot Technique to Monitor Direct Oral Anticoagulants: Clinical Validation of a UPLC-MS/MS-Based Assay. Anal Chem. 90(15):9395-9402.

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(2018). The impact of potentially inappropriate medication on the development of health care costs and its moderation by the number of prescribed substances. Results of a retrospective matched cohort study. PLoS One 13(7):e0198004.

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(2018). Changes in prescribed medicines in older patients with multimorbidity and polypharmacy in general practice. BMC Fam Pract 19(1):131.

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(2017). Combinations of QTc-prolonging drugs: towards disentangling pharmacokinetic and pharmacodynamic effects in their potentially additive nature. Ther Adv Psychopharmacol 7(12):251-264.

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(2017). Management of chronic pain using extended release tilidine : Quality of life and implication of comedication on tilidine metabolism. Schmerz 31(5):516-523.

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(2017). Association of preventable adverse drug events with inpatients' length of stay-A propensity-matched cohort study . Int J Clin Pract 71(10).

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(2017). Intracellular vorinostat accumulation and its relationship to histone deacetylase activity in soft tissue sarcoma patients . Cancer Chemother Pharmacol 80(2):433-439.

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(2017). Comparison of Nine Instruments to Calculate Anticholinergic Load in a Large Cohort of Older Outpatients: Association with Cognitive and Functional Decline, Falls, and Use of Laxatives . Am J Geriatr Psychiatry 25(5):531-540.

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(2017). Health Service Use, Costs, and Adverse Events Associated with Potentially Inappropriate Medication in Old Age in Germany: Retrospective Matched Cohort Study. Drugs Aging 34(4):289-301.

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(2017). How can we define and analyse drug exposure more precisely to improve the prediction of hospitalizations in longitudinal (claims) data?. Eur J Clin Pharmacol 73(3):373-380.

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(2017). Is Polypharmacy Associated with Frailty in Older People? Results From the ESTHER Cohort Study. J Am Geriatr Soc 65(2):e27-e32.

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(2017). Investigating the Additive Interaction of QT-Prolonging Drugs in Older People Using Claims Data. Drug Saf 40(2):133-144.

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(2016). Comparative evaluation of methods approximating drug prescription durations in claims data: modeling, simulation, and application to real data. Pharmacoepidemiol Drug Saf 25(12):1434-1442.

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(2016). SLCO1B1 Gene Variations Among Tanzanians, Ethiopians, and Europeans: Relevance for African and Worldwide Precision Medicine. OMICS 20(9):538-45.

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(2016). Longitudinal evaluation of medication underuse in older outpatients and its association with quality of life. Eur J Clin Pharmacol 72(7):877-85.

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(2015). Dried Blood Spot Technique for the Monitoring of Ambrisentan, Bosentan, Sildenafil, and Tadalafil in Patients with Pulmonary Arterial Hypertension. Anal Chem 87(24):12112-20.

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(2015). Role of NR1I2 (pregnane X receptor) polymorphisms in head and neck squamous cell carcinoma. Naunyn Schmiedebergs Arch Pharmacol 388(11):1141-50.

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(2015). The impact of pharmaceutical care interventions for medication underuse in older people: a systematic review and meta-analysis. Br J Clin Pharmacol 80(4):768-76.

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(2015). Medication Underuse in Aging Outpatients with Cardiovascular Disease: Prevalence, Determinants, and Outcomes in a Prospective Cohort Study. PLoS One 10(8):e0136339.

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(2015). Impact of an electronic clinical decision support system on workflow in antenatal care: the QUALMAT eCDSS in rural health care facilities in Ghana and Tanzania. Glob Health Action 8:25756.

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